American Cruise Lines Departing Ports

American Cruise Lines specializes in a unique style of small ship cruising along the inland waterways and rivers of the United States. Fascinating itineraries include the Pacific Northwest, Maine, New England Islands, Hudson River, Chesapeake Bay, the Historic South & Golden Isles, Florida, and the Mississippi River. With no more than 120 guests onboard, passengers experience each port of call, up close and personal, all while enjoying the camaraderie of fellow travelers and the exemplary service that is the hallmark of American Cruise Lines.

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